THE INTERCONNECTION OF ADIPONECTIN LEVELS WITH INDICES OF LIPID AND CARBOHYDRATE METABOLISM BY BOYS AND MEN WITH OBESITY, MANIFESTING AT PUBERTY

Mitroshina Ekaterina Vladimirovna, Senior laboratory assistant, sub-department of endocrinology, Samara State Medical University, mitro_31@mail.ru

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The study was designed to determine whether plasma adiponectin levels can be associated with lipid and carbohydrate metabolism in male patients with puberty-onset obesity. Baseline measurements included levels of adiponectin, plasma lipids, fasting plasma glucose and immunoreactive insulin in 77 male patients (47 adolescents and 30 men) and 22 control group members. The homeostasis model assessment (HOMA) score was also calculated. Mean adiponectin concentration levels did not differ between two groups and the controls, however the adolescents with BMI over 40 kg/m2 had hypoadiponectinemia. When divided into two subgroups with adiponectin levels below and over 10 mkg/ml, it was found that decreased adi-ponectin concentrations were associated with increased triglyceride levels and decreased levels of HDL-cholesterol in male adolescents with puberty-onset obesity. Adiponectin concentrations were negatively correlated with triglyceride and total cholesterol levels, fasting insulin and the severity of insulin resistance in men with puberty-onset obesity.

adiponectin, obesity, lipid metabolism, dyslipidemia, immunoreactive plasma insulin, insulin resistance.